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Lonza produces Bionomics' stem cell cancer drug

25 April 2013 | News | By BioSpectrum Bureau

Lonza manufactures Bionomics anti-cancer stem cell candidate BNC101

Lonza manufactures Bionomics anti-cancer stem cell candidate BNC101

Singapore: Bionomics has initiated manufacturing activities for BNC101, its lead anti-cancer stem cell candidate following completion of key preclinical studies. Lonza will manufacture BNC101 at its facility in Slough, UK.

Preclinical data has shown that BNC101 has demonstrated functional activity against LGR5, a high value cancer stem cell receptor. In addition, BNC101 significantly reduces cancer stem cell frequency and prevents tumour re-growth in long term animal studies involving primary colorectal cancer patient samples with multiple underlying gene mutations.

The clinical strategy for BNC101 will target solid tumours expressing LGR5 where there is a high rate of relapse. Colorectal cancer and pancreatic cancer have been chosen as initial priority indications.

Dr Deborah Rathjen, CEO and MD, Bionomics, said that, "The start of manufacturing activities for BNC101 signals a significant step towards clinical trials. We anticipate that Bionomics will commence clinical trials of BNC101 in 2014. BNC101 is a novel therapeutic antibody designed to target cancer stem cells. Eliminating cancer stem cells represents a new cancer treatment paradigm that could offer a distinct advantage over existing treatment strategies and a solution for resistance to chemotherapy."

Dr Christopher Reyes, VP, R&D, Biologics, said that, "We consider Lonza to be a leader in the area of contract development and manufacturing, and we are pleased to announce this important milestone in the BNC101 development program."


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