Topic: Single Cell Multi-omics Analysis of Differential Immune Response in Allergy and COVID-19

Synopsis:

Single cell whole transcriptome analysis is a powerful technology that can be used to study the expression of all genes in a single cell. This technology is especially powerful in revealing the molecular mechanisms of human infectious diseases and allergy and predicting immune response and treatment outcome.

In this webinar, Professor Rajesh Pandey of CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) will discuss studies that use single cell whole transcriptome technology to investigate the function of lncRNA in the development of infectious disease. Professor Menno van Zelm of Alfred Research Alliance (ARA) will talk about the important role of memory B-cell in mediating the beneficial effects of sublingual immunotherapy(SLIT) for grass pollen allergy.

The presenters will discuss:

1. The distinct roles of cell type-specific variant and invariant lncRNAs in immune response and house-keeping functions.
2. The involvement of NK, T, Naive B, Class switched memory B, and classical monocytes in lncRNA-mediated modulation of housekeeping functions.
3. Sublingual immunotherapy induces the appearance of two transcriptionally unique memory B cell fates.
4. Surface-expressed proteins on the memory B cells subsets can be used as early biomarkers for treatment effects for grass pollen allergy.

Key Learning Objectives: The findings of these studies have the potential to improve our understanding of infectious and allergy diseases and to develop new treatments and discover new biomakers.

Speakers: