Thursday, 28 March 2024


Panthera to evaluate AstraZeneca’s AZD7442 for the potential prevention of COVID-19

30 December 2020 | News

Trial treatment is aimed at helping those people with a compromised immune system, who cannot be vaccinated, vaccine-hesitant, and those who are unlikely to respond to a vaccination

Photo Credit: Freepik

Photo Credit: Freepik

Panthera’s clinical trial sites in Preston, North Manchester and North London began dosing volunteers in the Phase III PROVENT trial which will evaluate AstraZeneca’s long-acting antibody combination, AZD7442, for the potential prevention of COVID-19.  

The double-blind, placebo-controlled trial will include adult volunteers who have no history of COVID-19 and have an increased risk of infection, including those over 60, a BMI of over 30, a chronic medical condition, taking immunosuppressive medications or those more likely to be exposed, such as NHS workers, or those living in shared accommodation, such as students or the armed services.

The trial of AZD7442 single dose inoculation will run for a year and looks to recruit 5000 volunteers globally. The aim of the trial is to evaluate the safety and effectiveness of a combination of two long-acting monoclonal antibodies - man-made versions of naturally occurring human antibodies of the immune system - in preventing COVID-19 infection.

The "antibody combination" differs from a vaccine as it provides antibodies, rather than prompting the body's immune system to make them.

The treatment is aimed at helping those people with a compromised immune system, who cannot be vaccinated, vaccine hesitant and those who are unlikely to respond to a vaccination.

In the event of any volunteers developing COVID -19 symptoms Panthera will be providing support to the patient and ensuring the study can continue with those individuals safely isolated.

AstraZeneca's LAAB combination, AZD7442, has been engineered with AstraZeneca's proprietary half-life extension technology to increase the durability of the therapy for six to 12 months following a single administration. The inoculation combines two LAABs which are designed to increase the potency and reduce the risk of resistance being developed by the SARS-CoV-2 virus.

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