Indian researchers have developed a non-invasive, easy to administer, cost-effective, and patient compliant potential therapeutic strategy against Visceral Leishmaniasis, a neglected tropical disease.

Their strategy based on nano carrier-based oral drugs coated with Vitamin B₁₂ enhanced oral bioavailability and efficacy of the therapy by more than 90%.

Visceral Leishmaniasis (VL) is a complex infectious disease transmitted by the bite of female Phlebotomine sandflies. It is a neglected tropical disease that affects millions annually, making it the second most common parasitic killer after malaria. 

The researchers have developed a smart and intelligent nanocarrier utilizing the natural intrinsic Vitamin B₁₂ pathway present in human body that can mitigate stability challenges and drug-associated toxicity.

They have disguised the toxic but highly efficient drug of the disease within a biocompatible lipid nanocarrier shielding it from degradation in the hostile gastric environment, thus overcoming the gastrointestinal enzymatic barriers endured by any foreign synthetic drug molecule. 

Anchoring Vitamin B₁₂ on the surface of solid lipid nanoparticles augmented the stability and targeted delivery of the poorly soluble drugs and also enhanced the therapeutic efficiency with reduced risks of off-target actions.