Tuesday, 06 December 2022

Australia approves new treatment for rare cancer cholangiocarcinoma

16 September 2022 | News

The TGA approval follows PEMAZYRE's approval in the United States, Europe, Great Britain, Canada and Japan

image credit- shutterstock

image credit- shutterstock

A new targeted therapy to treat a rare bile duct cancer called cholangiocarcinoma has been approved for use in Australia.

PEMAZYRE (pemigatinib) has been provisionally approved by the Therapeutic Goods Administration (TGA) for the treatment of adult patients with locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement that has progressed after at least one prior line of systemic therapy.

The decision to approve this indication has been made on the basis of overall response rate (ORR) and duration of response (DOR). Continued approval of this indication depends on verification and description of benefit in confirmatory trial(s).

This means it will be available to Australian patients with cholangiocarcinoma who have been tested for an abnormal gene change in their tumour called an FGFR2 fusion or rearrangement – a defect that can drive cancer growth. This defect is estimated to be present in around 15% of patients diagnosed with cholangiocarcinoma.

PEMAZYRE, developed by US-based Incyte and partnered with independent pharmaceutical company Specialised Therapeutics (ST), in Singapore, for commercialisation in AustraliaNew Zealand and Singapore, belongs to a class of drugs called kinase inhibitors and works by blocking the abnormal FGFR2 protein in bile duct tumour cells and preventing cell growth.


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