Tuesday, 20 August 2019

Anaeropharma Science signs research agreement with Astellas

25 September 2018 | News

Under the terms of the agreement, the two companies shall conduct joint research regarding specific substances in order to create drug candidates for cancer therapy that utilizes Bifidobacterium as a drug delivery carrier.

Representative Image

Representative Image

Anaeropharma Science Inc. headquartered in Tokyo (hereafter "Anaeropharma") has announced that Anaeropharma and Astellas Pharma Inc. headquartered in Tokyo (hereafter "Astellas") have concluded a collaborative research agreement concerning the creation of novel anti-tumor drugs that utilizes characteristic features of Bifidobacterium longum through Anaeropharma's proprietary platform technology, in situ Delivery and Production System ("i-DPS").

An overview of the contract is as follows:

A collaborative research agreement concerning the creation of novel anti-tumor drugs that utilizes i-DPS technology

Under the terms of the agreement, the two companies shall conduct joint research regarding specific substances in order to create drug candidates for cancer therapy that utilizes Bifidobacterium as a drug delivery carrier. Astellas shall acquire the right of first negotiation regarding the exclusive licensing necessary for commercialization based on the results of this joint research. The agreement shall not constrain any research and development activities of i-DPS conducted by Anaeropharma applying to any molecules other than the above-mentioned specific substances.

About i-DPS and its Development Programs

Bifidobacterium is obligatory anaerobe which exists as enteroflora in the human body, and known as nonpathogenic bacteria. Solid cancers have immature vascular constructs and their interstitial tumors are in the state of hypoxia. The company aims to leverage the recombinant Bifidobacterium technology named i-DPS to create a new class of anti-cancer drugs. The technology offers broad potential to be more effective to solid tumors and generates anti-tumor drugs with less risks of adverse events than conventional anti-cancer drugs.

The leading development product using i-DPS technology, APS001F, a recombinant Bifidobacterium to express Cytosine Deaminase which converts a prodrug, 5-FC, to an anti-cancer drug, 5-FU, is under a phase 1 clinical trial in the U.S.

Comments

× Your session has been expired. Please click here to Sign-in or Sign-up
   New User? Create Account



Podcast

 

Survey Box

Will APAC lead the way for innovation in the field of precision medicine?

× Please select an option to participate in the poll.
Processing...   View poll results   More polls

× You have successfully cast your vote.
{{ optionDetail.option }}{{ optionDetail.percentage }}%
{{ optionDetail.percentage }}% Complete
More polls